10 Pragmatic Free Trial Tricks Experts Recommend

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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are typically described as focusing on practical aspects of study design which include the recruitment and consent process, as well as adherence and the use of standard equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which utilized various investigators and included participants from different geographical regions. This type of heterogeneity is essential for pragmatic trials to be able to prove their validity and reduces bias in the results. However excessive heterogeneity could lead to issues with the design of the trial.

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The goal of pragmatic trials is to simulate real-life scenarios and gain maximum validity externally. They are usually requested by policy makers and practitioners to aid in their decision-making. They are also a good way to identify the causality between the intervention and its effects. However, they should not be used in lieu for the use of explanation trials.

The idea of pragmatism is controversial and there are concerns about whether pragmatic trials can replace explanatory tests or if they should be an addition to them. Schwartz and Lellouch1 made a distinction between explanatory studies, which prove the physiological hypothesis or clinical hypothesis, as well as pragmatic trials that aid in the decision-making process for policy and practice. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool attempted to define the characteristics of a practical study that includes recruitment, design, delivery of the intervention and its follow-up.

There is a growing increase in the number of pragmatic trials that are published. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to controlled trials randomized to control (RCTs) produced 34 articles, as shown in red in Figure 2. This is a sign that the health sciences community is becoming increasingly sensitized to the subject of pragmatism. It is important to remember that the majority were conducted in primary-care settings.